Nitrous Oxide Sedation is a pleasant, relaxing feeling. It reduces anxiety, sensitivity to pain and gag reflexes. It will not put you to sleep.It's a safe and effective method of administering conscious sedation — which means that you'll stay awake during the procedure. But when nitrous oxide is used in combination with a local anesthetic, you won't feel pain or anxiety. In fact, many patients report a feeling of well-being during this type of sedation.